New research may have found a way to stop cancer cells (shown here) from creeping to other locations.Metastasis is the main cause of death in cancer, and current treatments against itare ineffective. But new research may have found a way to slow down, and perhaps even halt, the spread of cancer cells.Metastasisis the process by whichcancerspreads throughout the body.During this process, cancer cells may either invade nearby healthy tissue, penetrate the walls of lymph nodes, or enter the surrounding blood vessels.Butnew researchmay have found a way to control metastasis by inhibiting the migration of cancer cells. Stopping the cells from migrating is key in stopping metastasis.What enables cancer cells to migrateis a set of protrusions that help themto move. The team of researchers - led by Mostafa El-Sayed, Julius Brown Chair and Regents Professor of Chemistry and Biochemistry at Georgia Tech's School in Atlanta, GA - managed to successfully cut off these protrusions using a special technique.The findings were published in the journalPNAS.Breaking cancer cells' 'legs'The long, thinprotrusionsthat help cancer cells to move are called filopodia. They are an extension of a set of "broad, sheet-like" fibers called lamellipodia, which can be found around the edges of the cell.The suffix "-podia" (or "-podium," singular) comes from the Greek language and means "something footlike."Essentially, lamellipodia and filopodia are tiny "legs" that help healthy cells to move within the tissue. But in cancerous cells, lamellipodia and filopodia are produced in excess.The researchers used so-callednanorods, made of gold nanoparticles, to obstruct these tiny legs.With the help ofnanotechnology, scientists are able to reduce the sizeof certain materials to a nanoscale - with "nano" meaning the billionth part of a meter - at which point thesematerials start to show new chemical and physical properties.Prof. El-Sayed and colleagues introduced the nanorods locally. Thenanorods were covered with a coating of molecules, called RGD peptides, that made them attach to a specific kind of protein called integrin."The targeted nanorods tied up the integrin and blocked its functions, soit could not keep guiding the cytoskeleton to overproduce lamellipodia and filopodia," explains co-author Yan Tang, a postdoctoral assistant in computational biology.A cytoskeleton is the support structure of a cell, responsible for giving it a shape. It also has additional functions, with one of them being to form the filopodia protrusions.Method could kill cancer cellsThe experiments revealed that simply binding the nanorods to the integrin delayed the migration of the cancer cells.Importantly, this method avoided healthy cells, which could make this therapy drastically less damaging forpatients who undergo toxicchemotherapytreatment."There are certain, specific integrins that are overproduced in cancerous cells," explains Moustafa Ali, one of the study's first authors. "And you don't find them so much in healthy cells."In the second stage of the experiment, Prof. El-Sayed and team heated the gold nanoparticles with a laser of near-infrared light. This effectively stopped the migration of the malignant cells.
Comments
Post a Comment